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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K15
All Species:
5.76
Human Site:
S946
Identified Species:
15.83
UniProt:
Q6ZN16
Number Species:
8
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6ZN16
NP_001001671.2
1313
147437
S946
E
P
M
A
T
S
S
S
E
H
G
S
V
S
P
Chimpanzee
Pan troglodytes
XP_001171211
1375
154924
V986
S
S
S
E
Y
G
S
V
S
P
D
T
E
L
K
Rhesus Macaque
Macaca mulatta
XP_001111127
1297
143635
S936
P
S
A
S
P
I
P
S
A
D
S
T
T
Q
S
Dog
Lupus familis
XP_548885
1422
158482
E1035
L
A
L
P
S
S
G
E
P
M
G
S
S
S
S
Cat
Felis silvestris
Mouse
Mus musculus
A2AQW0
1331
149309
S952
E
L
V
G
S
S
S
S
E
H
G
S
I
S
P
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514080
1407
157705
S1025
S
S
E
H
G
S
V
S
P
D
C
D
L
Q
H
Chicken
Gallus gallus
XP_419725
1260
143069
V871
S
S
S
E
Y
G
S
V
S
P
D
T
E
L
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001155222
1364
153160
P976
S
E
Y
G
S
V
S
P
D
N
E
L
C
T
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001202919
1288
145042
P878
M
V
N
P
G
S
R
P
E
S
P
L
T
L
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58
44.2
81.6
N.A.
86
N.A.
N.A.
70.8
57.3
N.A.
54.4
N.A.
N.A.
N.A.
N.A.
45.4
Protein Similarity:
100
72.6
60.9
86.4
N.A.
90.3
N.A.
N.A.
79.4
73.5
N.A.
71.5
N.A.
N.A.
N.A.
N.A.
62.2
P-Site Identity:
100
6.6
6.6
26.6
N.A.
66.6
N.A.
N.A.
13.3
6.6
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
13.3
20
40
N.A.
86.6
N.A.
N.A.
20
13.3
N.A.
33.3
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
12
12
12
0
0
0
0
12
0
0
0
0
0
12
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
12
0
12
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
12
23
23
12
0
0
0
% D
% Glu:
23
12
12
23
0
0
0
12
34
0
12
0
23
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
23
23
23
12
0
0
0
34
0
0
0
0
% G
% His:
0
0
0
12
0
0
0
0
0
23
0
0
0
0
12
% H
% Ile:
0
0
0
0
0
12
0
0
0
0
0
0
12
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
23
% K
% Leu:
12
12
12
0
0
0
0
0
0
0
0
23
12
34
0
% L
% Met:
12
0
12
0
0
0
0
0
0
12
0
0
0
0
0
% M
% Asn:
0
0
12
0
0
0
0
0
0
12
0
0
0
0
12
% N
% Pro:
12
12
0
23
12
0
12
23
23
23
12
0
0
0
23
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
23
0
% Q
% Arg:
0
0
0
0
0
0
12
0
0
0
0
0
0
0
0
% R
% Ser:
45
45
23
12
34
56
56
45
23
12
12
34
12
34
23
% S
% Thr:
0
0
0
0
12
0
0
0
0
0
0
34
23
12
0
% T
% Val:
0
12
12
0
0
12
12
23
0
0
0
0
12
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
12
0
23
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _